{"id":738,"date":"2024-02-18T21:22:23","date_gmt":"2024-02-18T21:22:23","guid":{"rendered":"https:\/\/gebro.es\/?post_type=project&#038;p=738"},"modified":"2024-02-28T17:56:32","modified_gmt":"2024-02-28T17:56:32","slug":"research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy","status":"publish","type":"project","link":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/","title":{"rendered":"Research to Evaluate a New Treatment for Glioblastoma Based on Photodynamic Therapy"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p>Preclinical project based on the hypothesis that the combination of a photosensitizing drug such as 5-aminolevulinic acid (typically used to label glioblastoma tumor cells as a guide during surgical tumor resection) and a light source could function as a cytotoxic agent against the tumor, and consequently serve as a photodynamic treatment for glioblastoma. The primary objective of the project is to develop a new therapeutic approach for glioblastoma treatment. To achieve this, the following specific objectives are outlined:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Establish a technological platform based on an in vitro model of glioblastoma in human brain organoids, mini-brains, to replicate a 3D human model of glioblastoma.<\/li>\n<\/ol>\n\n\n\n<ol class=\"wp-block-list\" start=\"2\">\n<li>Conduct a proof-of-concept study based on photodynamic therapy using photosensitizing molecules as new antitumor agents.<\/li>\n<\/ol>\n\n\n\n<p>Positive results obtained in the initial phases of the study, published in the journal Cells, have motivated the planning of a new study phase focused on examining the contribution of the glioblastoma microenvironment to the response to photodynamic therapy in co-cultures of brain organoids.<\/p>\n\n\n\n<p>&nbsp;Pedrosa L et al.&nbsp; Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy. Cells. 2023 Apr 10;12(8):1125<\/p>\n\n\n\n<p>Collaborating entities:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Experimental Neurosurgical Oncology Laboratory, Hospital Cl\u00ednic de Barcelona<\/li>\n\n\n\n<li>August Pi i Sunyer Biomedical Research Institute (IDIBAPS) <\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Department of Cellular Biology, Physiology, and Immunology, Faculty of Biology, University of Barcelona<\/li>\n\n\n\n<li>Institute of Environmental Diagnosis and Water Studies (IDAEA-CSIC)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Experimental Neurosurgical Oncology Laboratory, Hospital Cl\u00ednic de Barcelona<\/li>\n\n\n\n<li>August Pi i Sunyer Biomedical Research Institute (IDIBAPS) <\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Duration<br><\/h2>\n\n\n\n<p>2019-2023<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Preclinical project based on the hypothesis that the combination of a photosensitizing drug such as 5-aminolevulinic acid (typically used to label glioblastoma tumor cells as a guide during surgical tumor resection) and a light source&#8230;<\/p>\n","protected":false},"featured_media":740,"parent":0,"menu_order":13,"template":"","class_list":["post-738","project","type-project","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Science and research - Gebro Pharma<\/title>\n<meta name=\"description\" content=\"We are committed to an innovation strategy together with prestigious scientific partners to create new solutions in our therapeutic areas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science and research - Gebro Pharma\" \/>\n<meta property=\"og:description\" content=\"We are committed to an innovation strategy together with prestigious scientific partners to create new solutions in our therapeutic areas.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/\" \/>\n<meta property=\"og:site_name\" content=\"Gebro Pharma\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-28T17:56:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/gebro.es\/app\/uploads\/2024\/02\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1639\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/\",\"url\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/\",\"name\":\"Science and research - Gebro Pharma\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/gebro.es\\\/app\\\/uploads\\\/2024\\\/02\\\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg\",\"datePublished\":\"2024-02-18T21:22:23+00:00\",\"dateModified\":\"2024-02-28T17:56:32+00:00\",\"description\":\"We are committed to an innovation strategy together with prestigious scientific partners to create new solutions in our therapeutic areas.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/#primaryimage\",\"url\":\"https:\\\/\\\/gebro.es\\\/app\\\/uploads\\\/2024\\\/02\\\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/gebro.es\\\/app\\\/uploads\\\/2024\\\/02\\\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg\",\"width\":2560,\"height\":1639},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\",\"item\":\"https:\\\/\\\/gebro.es\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Projects\",\"item\":\"https:\\\/\\\/gebro.es\\\/en\\\/science-research\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research to Evaluate a New Treatment for Glioblastoma Based on Photodynamic Therapy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/gebro.es\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/gebro.es\\\/en\\\/\",\"name\":\"Gebro Pharma\",\"description\":\"At Gebro Pharma we improve your health\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/gebro.es\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Science and research - Gebro Pharma","description":"We are committed to an innovation strategy together with prestigious scientific partners to create new solutions in our therapeutic areas.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/","og_locale":"en_US","og_type":"article","og_title":"Science and research - Gebro Pharma","og_description":"We are committed to an innovation strategy together with prestigious scientific partners to create new solutions in our therapeutic areas.","og_url":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/","og_site_name":"Gebro Pharma","article_modified_time":"2024-02-28T17:56:32+00:00","og_image":[{"width":2560,"height":1639,"url":"https:\/\/gebro.es\/app\/uploads\/2024\/02\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/","url":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/","name":"Science and research - Gebro Pharma","isPartOf":{"@id":"https:\/\/gebro.es\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/#primaryimage"},"image":{"@id":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/gebro.es\/app\/uploads\/2024\/02\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg","datePublished":"2024-02-18T21:22:23+00:00","dateModified":"2024-02-28T17:56:32+00:00","description":"We are committed to an innovation strategy together with prestigious scientific partners to create new solutions in our therapeutic areas.","breadcrumb":{"@id":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/#primaryimage","url":"https:\/\/gebro.es\/app\/uploads\/2024\/02\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg","contentUrl":"https:\/\/gebro.es\/app\/uploads\/2024\/02\/FOTO-GRUP-GLIOBLASTOMA_1-scaled.jpg","width":2560,"height":1639},{"@type":"BreadcrumbList","@id":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"","item":"https:\/\/gebro.es\/en\/"},{"@type":"ListItem","position":2,"name":"Projects","item":"https:\/\/gebro.es\/en\/science-research\/"},{"@type":"ListItem","position":3,"name":"Research to Evaluate a New Treatment for Glioblastoma Based on Photodynamic Therapy"}]},{"@type":"WebSite","@id":"https:\/\/gebro.es\/en\/#website","url":"https:\/\/gebro.es\/en\/","name":"Gebro Pharma","description":"At Gebro Pharma we improve your health","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/gebro.es\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/project\/738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/types\/project"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/media\/740"}],"wp:attachment":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/media?parent=738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}