{"id":738,"date":"2024-02-18T21:22:23","date_gmt":"2024-02-18T21:22:23","guid":{"rendered":"https:\/\/gebro.es\/?post_type=project&#038;p=738"},"modified":"2024-02-28T17:56:32","modified_gmt":"2024-02-28T17:56:32","slug":"research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy","status":"publish","type":"project","link":"https:\/\/gebro.es\/en\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/","title":{"rendered":"Research to Evaluate a New Treatment for Glioblastoma Based on Photodynamic Therapy"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Preclinical project based on the hypothesis that the combination of a photosensitizing drug such as 5-aminolevulinic acid (typically used to label glioblastoma tumor cells as a guide during surgical tumor resection) and a light source could function as a cytotoxic agent against the tumor, and consequently serve as a photodynamic treatment for glioblastoma. The primary objective of the project is to develop a new therapeutic approach for glioblastoma treatment. To achieve this, the following specific objectives are outlined:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Establish a technological platform based on an in vitro model of glioblastoma in human brain organoids, mini-brains, to replicate a 3D human model of glioblastoma.<\/li>\n<\/ol>\n\n\n\n<ol class=\"wp-block-list\" start=\"2\">\n<li>Conduct a proof-of-concept study based on photodynamic therapy using photosensitizing molecules as new antitumor agents.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Positive results obtained in the initial phases of the study, published in the journal Cells, have motivated the planning of a new study phase focused on examining the contribution of the glioblastoma microenvironment to the response to photodynamic therapy in co-cultures of brain organoids.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;Pedrosa L et al.&nbsp; Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy. Cells. 2023 Apr 10;12(8):1125<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Collaborating entities:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Experimental Neurosurgical Oncology Laboratory, Hospital Cl\u00ednic de Barcelona<\/li>\n\n\n\n<li>August Pi i Sunyer Biomedical Research Institute (IDIBAPS) <\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Department of Cellular Biology, Physiology, and Immunology, Faculty of Biology, University of Barcelona<\/li>\n\n\n\n<li>Institute of Environmental Diagnosis and Water Studies (IDAEA-CSIC)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Experimental Neurosurgical Oncology Laboratory, Hospital Cl\u00ednic de Barcelona<\/li>\n\n\n\n<li>August Pi i Sunyer Biomedical Research Institute (IDIBAPS) <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Duration<br><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2019-2023<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Preclinical project based on the hypothesis that the combination of a photosensitizing drug such as 5-aminolevulinic acid (typically used to label glioblastoma tumor cells as a guide during surgical tumor resection) and a light source&#8230;<\/p>\n","protected":false},"featured_media":740,"parent":0,"menu_order":13,"template":"","class_list":["post-738","project","type-project","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/project\/738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/types\/project"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/media\/740"}],"wp:attachment":[{"href":"https:\/\/gebro.es\/en\/wp-json\/wp\/v2\/media?parent=738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}