{"id":1575,"date":"2024-02-18T21:22:23","date_gmt":"2024-02-18T21:22:23","guid":{"rendered":"https:\/\/gebro.es\/science-research\/research-to-evaluate-a-new-treatment-for-glioblastoma-based-on-photodynamic-therapy\/"},"modified":"2025-02-20T18:19:57","modified_gmt":"2025-02-20T18:19:57","slug":"investigacio-per-avaluar-un-nou-tractament-per-al-glioblastoma-basat-en-terapia-fotodinamica","status":"publish","type":"project","link":"https:\/\/gebro.es\/ca\/ciencia-i-recerca\/investigacio-per-avaluar-un-nou-tractament-per-al-glioblastoma-basat-en-terapia-fotodinamica\/","title":{"rendered":"Investigaci\u00f3 per avaluar un nou tractament per al glioblastoma basat en ter\u00e0pia fotodin\u00e0mica"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Resum<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><br>Projecte precl\u00ednic que parteix de la hip\u00f2tesi que la combinaci\u00f3 d\u2019un f\u00e0rmac fotosensibilitzador com pot ser l\u2019\u00e0cid 5-aminolevul\u00ednic (un agent t\u00edpicament emprat per al marcatge de les c\u00e8l\u00b7lules tumorals del glioblastoma com a guia durant la resecci\u00f3 quir\u00fargica del tumor) i una font de llum, podria funcionar com a agent citot\u00f2xic contra el tumor, i, conseq\u00fcentment com a tractament fotodin\u00e0mic per al glioblastoma. En base a aix\u00f2, l\u2019objectiu principal del projecte se centra en desenvolupar un nou enfocament terap\u00e8utic per al tractament del glioblastoma. Per tal d\u2019assolir-ho es plantegen els objectius espec\u00edfics seg\u00fcents:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Establir una plataforma tecnol\u00f2gica basada en un model in vitro de glioblastoma a organoides cerebrals humans, mini-brains, per tal de replicar un model hum\u00e0 3D de glioblastoma.<\/li>\n<\/ol>\n\n\n\n<ol start=\"2\" class=\"wp-block-list\">\n<li>Realitzar una prova de concepte basada en ter\u00e0pia fotodin\u00e0mica emprant mol\u00e8cules fotosensibilitzadores com a nous agents antitumorals.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><br><br>Els bons resultat obtinguts en les primeres fases de l\u2019estudi, publicats a la revista Cells1, han motiva la planificaci\u00f3 d\u2019una nova fase d\u2019estudi enfocada a estudiar la contribuci\u00f3 del microentorn del glioblastoma en la resposta a la ter\u00e0pia fotodin\u00e0mica en co-cultius d\u2019organoides cerebrals.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1-Pedrosa L et al.&nbsp; Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy. Cells. 2023 Apr 10;12(8):1125<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Entitats col\u00b7laboradores<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Laboratori Experimental d&#8217;Oncologia Neuroquir\u00fargica de l&#8217;Hospital Cl\u00ednic de Barcelona<\/li>\n\n\n\n<li>Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer\u00a0 (IDIBAPS)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Departament de Biologia Celular, Fisiologia i Inmunologia de la <a href=\"https:\/\/www.ub.edu\/portal\/web\/biologia\/\">Facultat de Biologia de la Universitat de Barcelona<\/a><\/li>\n\n\n\n<li>Instituto de Diagn\u00f3stico Ambiental y Estudios del Agua (IDAEA-CSIC)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Durada<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2019-2023<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Resum Projecte precl\u00ednic que parteix de la hip\u00f2tesi que la combinaci\u00f3 d\u2019un f\u00e0rmac fotosensibilitzador com pot ser l\u2019\u00e0cid 5-aminolevul\u00ednic (un agent t\u00edpicament emprat per al marcatge de les c\u00e8l\u00b7lules tumorals del glioblastoma com a guia durant la resecci\u00f3 quir\u00fargica del tumor) i una font de llum, podria funcionar com a agent citot\u00f2xic contra el tumor, [&hellip;]<\/p>\n","protected":false},"featured_media":1576,"parent":0,"menu_order":9,"template":"","class_list":["post-1575","project","type-project","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/gebro.es\/ca\/wp-json\/wp\/v2\/project\/1575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gebro.es\/ca\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/gebro.es\/ca\/wp-json\/wp\/v2\/types\/project"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gebro.es\/ca\/wp-json\/wp\/v2\/media\/1576"}],"wp:attachment":[{"href":"https:\/\/gebro.es\/ca\/wp-json\/wp\/v2\/media?parent=1575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}